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High quality Camptothecin P.E

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seat: Beijing
Validity to: Long-term effective
Last update: 2017-12-22 20:56
Browse the number: 36
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Camptothecin P.E

Specifications:1.From fruit and leaves 

2. Light yellow needle crystal 

3. 95~99%(HPLC) 

 Camptothecin

 Quick Details

 

Specifications

 1. From fruit and leaves of the plant Camptotheca acurminata.

2. Light yellow needle crystal

3. 95~99%(HPLC)

 [Chemical Name]: 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]

indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione

[Product Resource]: From fruit and leaves of the plant Camptotheca acurminata

(Camptotheca, Happy tree), a tree native in China. 

[Molecular Formula]: C20H16N2O4[Molecular Weight]: 348.36 [CAS Number]:

7689-03-4

 

[Application Scope]: antitumour, immunosuppressant, antivirus.

 [Other Information]: Camptothecin (CPT) is a cytotoxic quinoline alkaloid which

 inhibits the DNA  enzyme topoisomeraseI (topo I). It was discovered in 1966 by

 M. E. Wall and M. C. Wani in systematic screening of natural products for

 anticancer drugs. CPT showed remarkable anticancer activity in preliminary

 clinical trials but also low solubility and advers drug reaction. Because of

 these disadvantages researchers have made numbers of derivatives to increase the

 benefits of the chemical, with good results. Two CPT analogues have been

 approved and are used in cancer chemotherapy today, topotecan and irinotecan.

 

 

 

 

 

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